MLF1 Antibody
Product Specifications
Background
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
NCBI Gene ID
4291
Swiss Prot
P58340
Accession Number
P58340
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human MLF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MLF1
NCBI Official Name
Myeloid leukemia factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Li, Z.F., J. Neurol. Sci. 264 (1-2), 77-86 (2008)
Background Reference 02
Yoneda-Kato, N., EMBO J. 24 (9), 1739-1749 (2005)
Other Product Names
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Tested Applications
WB
Protein ID
17368170
Physical Properties
Liquid
Curated Selection
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