OGT Antibody

Product Specifications

Background

O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal.

NCBI Gene ID

8473

Swiss Prot

O15294

Accession Number

O15294

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This OGT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1017-1046 amino acids from the C-terminal region of human OGT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

117 kDa

Fragment

Rabbit Ig

Symbol

OGT

NCBI Official Name

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

NCBI Organism

Homo sapiens

Background Reference 01

Roeder, R.G., Nature 459 (7245), 455-459 (2009)

Background Reference 02

Taylor, R.P., J. Biol. Chem. 284 (6), 3425-3432 (2009)

Background Reference 03

Slawson, C., Mol. Biol. Cell 19 (10), 4130-4140 (2008)

Other Product Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT, OGT