PRELP Antibody
Product Specifications
Background
PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.
NCBI Gene ID
5549
Swiss Prot
P51888
Accession Number
P51888
Host
Rabbit
Reactivity
Human
Immunogen
This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human PRELP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
PRELP
NCBI Official Name
Prolargin
NCBI Organism
Homo sapiens
Background Reference 01
Ehret, G.B., et al. Eur. J. Hum. Genet. 17 (12) :1650-1657 (2009)
Background Reference 02
Grover, J., et al. Matrix Biol. 26 (2) :140-143 (2007)
Background Reference 03
Johnson, J.M., et al. Mol. Vis. 12, 1057-1066 (2006)
Other Product Names
Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A
Tested Applications
WB, IHC-P
Protein ID
1709586
Physical Properties
Liquid
Curated Selection
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