TDG Antibody
Product Specifications
Background
The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.
NCBI Gene ID
6996
Swiss Prot
Q13569
Accession Number
Q13569
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TDG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human TDG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Symbol
TDG
NCBI Official Name
G/T mismatch-specific thymine DNA glycosylase
NCBI Organism
Homo sapiens
Background Reference 01
Kim, E.J., Biochem. Biophys. Res. Commun. 377 (3), 838-842 (2008)
Background Reference 02
Neddermann, P., J. Biol. Chem. 271 (22), 12767-12774 (1996)
Other Product Names
G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, hTDG, TDG
Tested Applications
WB, Flow
Protein ID
46397791
Physical Properties
Liquid
Curated Selection
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