ALS2 Antibody
Product Specifications
Background
ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.
NCBI Gene ID
57679
Swiss Prot
Q96Q42
Accession Number
Q96Q42
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ALS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1248-1277 amino acids from the C-terminal region of human ALS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=62-280
Calculated Molecular Weight
184 kDa
Fragment
Rabbit Ig
Symbol
ALS2
NCBI Official Name
Alsin
NCBI Organism
Homo sapiens
Background Reference 01
Soares, D.C., Mol Model 15 (2), 113-122 (2009)
Background Reference 02
Mintchev, N., Neurology 72 (1), 28-32 (2009)
Other Product Names
Alsin, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 protein, ALS2, ALS2CR6, KIAA1563
Tested Applications
WB, IHC-P
Protein ID
296434394
Physical Properties
Liquid
Curated Selection
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