Drosophila Parkin Antibody
Product Specifications
Background
Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.
NCBI Gene ID
40336
Swiss Prot
Q7KTX7
Accession Number
Q7KTX7
Host
Rabbit
Reactivity
Drosophila
Immunogen
This Drosophila Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from the N-terminal region of human Drosophila Parkin.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Q7KTX7
NCBI Official Name
CG10523-PB, isoform B
NCBI Organism
Drosophila melanogaster
Background Reference 01
Zhong, L. et al. J. Biol. Chem. 280 (10), 9425-9430 (2005)
Background Reference 02
Pesah, Y. et al. Development 131 (9), 2183-2194 (2004)
Background Reference 03
Haywood, A.F. et al. BMC Neurosci 5, 14 (2004)
Background Reference 04
Finney, N. et al. J. Biol. Chem. 278 (18), 16054-16058 (2003)
Other Product Names
CG10523-PB; isoform B; Cg10523-pc; isoform c; PARKIN; park; parkin
Tested Applications
WB
Physical Properties
Liquid
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