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Drosophila Parkin Antibody

Product Specifications

Background

Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.

NCBI Gene ID

40336

Swiss Prot

Q7KTX7

Accession Number

Q7KTX7

Host

Rabbit

Reactivity

Drosophila

Immunogen

This Drosophila Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from the N-terminal region of human Drosophila Parkin.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-278

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Q7KTX7

NCBI Official Name

CG10523-PB, isoform B

NCBI Organism

Drosophila melanogaster

Background Reference 01

Zhong, L. et al. J. Biol. Chem. 280 (10), 9425-9430 (2005)

Background Reference 02

Pesah, Y. et al. Development 131 (9), 2183-2194 (2004)

Background Reference 03

Haywood, A.F. et al. BMC Neurosci 5, 14 (2004)

Background Reference 04

Finney, N. et al. J. Biol. Chem. 278 (18), 16054-16058 (2003)

Other Product Names

CG10523-PB; isoform B; Cg10523-pc; isoform c; PARKIN; park; parkin

Tested Applications

WB

Physical Properties

Liquid

Curated Selection

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