ZBTB7B Antibody

Product Specifications

Background

ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

NCBI Gene ID

51043

Swiss Prot

O15156

Accession Number

O15156

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the Central region of human ZBTB7B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Symbol

ZBTB7B

NCBI Official Name

Zinc finger and BTB domain-containing protein 7B

NCBI Organism

Homo sapiens

Background Reference 01

Galera, P., Proc. Natl. Acad. Sci. U.S.A. 91 (20), 9372-9376 (1994)

Background Reference 02

Widom, R.L., Gene 198 (1-2), 407-420 (1997)

Background Reference 03

Heegaard, A.M., J. Bone Miner. Res. 12 (12), 2050-2060 (1997)

Background Reference 04

Widom, R.L., Matrix Biol. 20 (7), 451-462 (2001)

Other Product Names

Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B