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CLC4 Antibody

Product Specifications

Background

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.

NCBI Gene ID

1183

Swiss Prot

P51793

Accession Number

P51793

Host

Rabbit

Reactivity

Human

Immunogen

This CLC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-251

Calculated Molecular Weight

85 kDa

Fragment

Rabbit Ig

Symbol

CLCN4

NCBI Official Name

H (+) /Cl (-) exchange transporter 4

NCBI Organism

Homo sapiens

Background Reference 01

Wang, T., et al., Gastroenterology 126 (4) :1157-1166 (2004) .

Background Reference 02

Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31 (3) :657-666 (1999) .

Background Reference 03

Dinulos, M.B., et al., Genomics 35 (1) :244-247 (1996) .

Background Reference 04

Schnur, R.E., et al., Hum. Genet. 95 (5) :594-595 (1995) .

Other Product Names

H (+) /Cl (-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4

Tested Applications

WB, IHC-P, IF

Protein ID

20141247

Physical Properties

Liquid

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