Kallikrein 5 Antibody
Product Specifications
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK5 expression is up-regulated by estrogens and progestins. The protein is secreted and may be involved in desquamation in the epidermis.
NCBI Gene ID
25818
Swiss Prot
Q9Y337
Accession Number
Q9Y337
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Kallikrein 5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-174 amino acids from the Central region of human Kallikrein 5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KLK5
NCBI Official Name
Kallikrein-5
NCBI Organism
Homo sapiens
Background Reference 01
Planque, C., et al., Biochem. Biophys. Res. Commun. 329 (4) :1260-1266 (2005) . Michael, I.P., et al., J. Biol. Chem. 280 (15) :14628-14635 (2005) . Ishida-Yamamoto, A., et al., J. Invest. Dermatol. 124 (2) :360-366 (2005) . Brattsand, M., et al., J. Invest. Dermatol. 124 (1) :198-203 (2005) . Caubet, C., et al., J. Invest. Dermatol. 122 (5) :1235-1244 (2004) .
Other Product Names
Kallikrein-5, 3421-, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, KLK5, SCTE
Tested Applications
WB
Protein ID
296434569
Physical Properties
Liquid
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