Kallikrein 3 Antibody

Product Specifications

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK3 is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.

NCBI Gene ID

354

Swiss Prot

P07288

Accession Number

P07288

Host

Rabbit

Reactivity

Human

Immunogen

This Kallikrein 3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-250 amino acids from the C-terminal region of human Kallikrein 3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

29 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KLK3

NCBI Official Name

Prostate-specific antigen

NCBI Organism

Homo sapiens

Background Reference 01

Binnie, M.C., et al., Prostate 63 (4) :309-315 (2005) .

Background Reference 02

Habib, F.K., et al., Int. J. Cancer 114 (2) :190-194 (2005) .

Background Reference 03

Laidler, P., et al., Arch. Biochem. Biophys. 435 (1) :1-14 (2005) .

Background Reference 04

Dallas, S.L., et al., J. Cell. Physiol. 202 (2) :361-370 (2005) .

Other Product Names

Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS

Tested Applications

Protein ID

130989

Physical Properties

Liquid

Curated Selection

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