RCAN1/DSCR1 Antibody

Product Specifications

Background

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

NCBI Gene ID

1827

Swiss Prot

P53805

Accession Number

P53805

Host

Rabbit

Reactivity

Human

Immunogen

This RCAN1/DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Hamster, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RCAN1

NCBI Official Name

Calcipressin-1

NCBI Organism

Homo sapiens

Background Reference 01

Minami, T., et al., J. Biol. Chem. 279 (48) :50537-50554 (2004) . Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321 (3) :648-656 (2004) . Michtalik, H.J., et al., Free Radic. Biol. Med. 37 (4) :454-462 (2004) . Hesser, B.A., et al., Blood 104 (1) :149-158 (2004) . Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41 (4) :334-344 (2004) .

Other Product Names

Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1