DSCR1 Antibody

DSCR1 (calcipressin 1) interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Thr gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

This DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human DSCR1.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Minami, T., et al., J. Biol. Chem. 279 (48) :50537-50554 (2004) . Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321 (3) :648-656 (2004) . Michtalik, H.J., et al., Free Radic. Biol. Med. 37 (4) :454-462 (2004) . Hesser, B.A., et al., Blood 104 (1) :149-158 (2004) . Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41 (4) :334-344 (2004) .

Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1