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ATF4 Antibody

Product Specifications

Background

ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . ATF4 belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain.

NCBI Gene ID

468

Swiss Prot

Q96AQ3

Accession Number

Q96AQ3

Host

Rabbit

Reactivity

Human

Immunogen

This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-252 amino acids from human ATF4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-224

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ATF4

NCBI Official Name

ATF4 protein

NCBI Organism

Homo sapiens

Background Reference 01

Gombart, A.F., J. Leukoc. Biol. 81 (6), 1535-1547 (2007)

Background Reference 02

Jousse, C., J. Biol. Chem. 282 (21), 15851-15861 (2007)

Background Reference 03

Kakiuchi, C., Neurosci. Lett. 417 (3), 316-321 (2007)

Background Reference 04

Marchand, A., J. Biol. Chem. 281 (28), 19124-19133 (2006)

Other Product Names

Tax-responsive enhancer element B67; ATF4 protein

Tested Applications

WB

Physical Properties

Liquid

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