Cdc6 Antibody

Product Specifications

Background

Human Cdc6 is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

NCBI Gene ID

990

Swiss Prot

Q99741

Accession Number

Q99741

Host

Rabbit

Reactivity

Human

Immunogen

This Cdc6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human Cdc6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

63 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CDC6

NCBI Official Name

Cell division control protein 6 homolog

NCBI Organism

Homo sapiens

Background Reference 01

Alexandrow, M.G., et al., Mol. Cell. Biol. 24 (4) :1614-1627 (2004) .

Background Reference 02

Yim, H., et al., Mol. Biol. Cell 14 (10) :4250-4259 (2003) .

Background Reference 03

Clay-Farrace, L., et al., EMBO J. 22 (3) :704-712 (2003) .

Background Reference 04

Pelizon, C., et al., EMBO Rep. 3 (8) :780-784 (2002) .

Other Product Names

Cell division control protein 6 homolog, CDC6-related protein, Cdc18-related protein, HsCdc18, p62 (cdc6), HsCDC6, CDC6, CDC18L

Tested Applications

Protein ID

50400620

Physical Properties

Liquid

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