27Kip1 Antibody

Product Specifications

Background

P27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

NCBI Gene ID

1027

Swiss Prot

P46527

Accession Number

P46527

Host

Rabbit

Reactivity

Human

Immunogen

This 27Kip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the C-terminal region of human 27Kip1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Hamster

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

CDKN1B

NCBI Official Name

Cyclin-dependent kinase inhibitor 1B

NCBI Organism

Homo sapiens

Background Reference 01

Kawamata, N., et al., Eur. J. Haematol. 74 (5) :424-429 (2005) .

Background Reference 02

Andreu, E.J., et al., Cancer Res. 65 (8) :3264-3272 (2005) .

Background Reference 03

Wingate, H., et al., J. Biol. Chem. 280 (15) :15148-15157 (2005) .

Background Reference 04

Wang, C., et al., J. Biol. Chem. 280 (13) :12339-12343 (2005) .

Other Product Names

Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1

Tested Applications

WB, IF

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP3-23896-100ug 100 µg

Mouse Monoclonal GCLM Antibody (GCLM/4069)

Ask

View Details

A23597-100UG 100 µg

OR52K1 Antibody

Ask

View Details

RC210914L1V 200 µL

AVPR V2 (AVPR2) (NM_000054) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

510905 100 µg

KIF12 discontinued

Ask

View Details

NBP2-81828JF646 0.1 mL

Rabbit Polyclonal SLAIN1 Antibody [Janelia Fluor 646]

Ask

View Details