SOST Antibody
Product Specifications
Background
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of the sclerostin gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
NCBI Gene ID
50964
Swiss Prot
Q9BQB4
Accession Number
Q9BQB4
Host
Rabbit
Reactivity
Human
Immunogen
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human SOST.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Symbol
SOST
NCBI Official Name
Sclerostin
NCBI Organism
Homo sapiens
Background Reference 01
Semenov, M.V., J. Biol. Chem. 281 (50), 38276-38284 (2006)
Background Reference 02
Ellies, D.L., J. Bone Miner. Res. 21 (11), 1738-1749 (2006)
Background Reference 03
Balemans, W., Musculoskelet Neuronal Interact (4), 355-356 (2006)
Background Reference 04
Gardner, J.C., J. Clin. Endocrinol. Metab. 90 (12), 6392-6395 (2005)
Other Product Names
Sclerostin, SOST
Tested Applications
WB, IHC-P
Protein ID
20140220
Physical Properties
Liquid
Curated Selection
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