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ST14 Antibody

Product Specifications

Background

ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

NCBI Gene ID

6768

Swiss Prot

Q9Y5Y6

Accession Number

Q9Y5Y6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ST14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-855 amino acids from the C-terminal region of human ST14.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-196

Calculated Molecular Weight

95 kDa

Fragment

Rabbit Ig

Symbol

ST14

NCBI Official Name

Suppressor of tumorigenicity 14 protein

NCBI Organism

Homo sapiens

Background Reference 01

Santin, A.D., et al., Cancer 98 (9) :1898-1904 (2003) .

Background Reference 02

Oberst, M.D., et al., J. Biol. Chem. 278 (29) :26773-26779 (2003) .

Background Reference 03

Ihara, S., et al., J. Biol. Chem. 277 (19) :16960-16967 (2002) .

Background Reference 04

Benaud, C.M., et al., Clin. Exp. Metastasis 19 (7) :639-649 (2002) .

Other Product Names

Suppressor of tumorigenicity 14 protein, Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein, ST14, PRSS14, SNC19, TADG15

Tested Applications

WB, IHC-P

Protein ID

13124575

Physical Properties

Liquid

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