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M Sirt3 Antibody

Product Specifications

Background

SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.

NCBI Gene ID

64384

Swiss Prot

Q8R104

Accession Number

Q8R104

Host

Rabbit

Reactivity

Mouse, Hamster

Immunogen

This Sirt3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-334 amino acids from the C-terminal region of Mouse Sirt3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-194

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Symbol

Sirt3

NCBI Official Name

NAD-dependent protein deacetylase sirtuin-3

NCBI Organism

Mus musculus

Background Reference 01

Hirschey, M.D., et al. Nature 464 (7285) :121-125 (2010)

Background Reference 02

Pillai, V.B., et al. J. Biol. Chem. 285 (5) :3133-3144 (2010)

Background Reference 03

Kim, H.S., et al. Cancer Cell 17 (1) :41-52 (2010)

Other Product Names

NAD-dependent protein deacetylase sirtuin-3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, mSIR2L3, Sirt3, Sir2l3

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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