OAS1 Antibody

Product Specifications

Background

OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP (A2'P5'A) N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

NCBI Gene ID

4938

Swiss Prot

P00973

Accession Number

P00973

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This OAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human OAS1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Symbol

OAS1

NCBI Official Name

2'-5'-oligoadenylate synthase 1

NCBI Organism

Homo sapiens

Background Reference 01

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

Background Reference 02

Sarkar, S.N., et al., J. Biol. Chem. 274 (36) :25535-25542 (1999) .

Background Reference 03

Ghosh, A., et al., J. Biol. Chem. 272 (52) :33220-33226 (1997) .

Background Reference 04

Ghosh, S.K., et al., J. Biol. Chem. 266 (23) :15293-15299 (1991) .

Other Product Names

2'-5'-oligoadenylate synthase 1, (2-5') oligo (A) synthase 1, 2-5A synthase 1, E18/E16, p46/p42 OAS, OAS1, OIAS

Tested Applications

WB, IHC-P

Protein ID

296439492

Physical Properties

Liquid

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