MVP Antibody
Product Specifications
Background
MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.
NCBI Gene ID
9961
Swiss Prot
Q14764
Accession Number
Q14764
Host
Rabbit
Reactivity
Human
Immunogen
This MVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 863-893 amino acids from the C-terminal region of human MVP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
99 kDa
Fragment
Rabbit Ig
Symbol
MVP
NCBI Official Name
Major vault protein
NCBI Organism
Homo sapiens
Background Reference 01
Aronica, E., et al., Epilepsia 44 (9) :1166-1175 (2003) .
Background Reference 02
Klunder, J.W., et al., Hum. Pathol. 34 (2) :150-155 (2003) .
Background Reference 03
Burger, H., et al., Clin. Cancer Res. 9 (2) :827-836 (2003) .
Background Reference 04
Yu, Z., et al., J. Biol. Chem. 277 (43) :40247-40252 (2002) .
Other Product Names
Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
Tested Applications
WB, IHC-P, Flow
Protein ID
21542417
Physical Properties
Liquid
Curated Selection
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