MMP8 Antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP8 is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

This MMP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human MMP8.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Van den Steen, P.E., et al., Biochem. Biophys. Res. Commun. 310 (3) :889-896 (2003) . Giambernardi, T.A., et al., Matrix Biol. 20 (8) :577-587 (2001) . Nagase, H., et al., J. Biol. Chem. 274 (31) :21491-21494 (1999) . Massova, I., et al., FASEB J. 12 (12) :1075-1095 (1998) . Pendas, A.M., et al., Genomics 37 (2) :266-268 (1996) .