MMP3 Antibody
Product Specifications
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
NCBI Gene ID
4314
Swiss Prot
P08254
Accession Number
P08254
Host
Rabbit
Reactivity
Human
Immunogen
This MMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the Central region of human MMP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
MMP3
NCBI Official Name
Stromelysin-1
NCBI Organism
Homo sapiens
Background Reference 01
Sage, E.H., et al., J. Biol. Chem. 278 (39) :37849-37857 (2003) .
Background Reference 02
Matsuyama, A., et al., Circulation 108 (12) :1469-1473 (2003) .
Background Reference 03
Mercapide, J., et al., Int. J. Cancer 106 (5) :676-682 (2003) .
Background Reference 04
Bodemer, C., et al., J. Invest. Dermatol. 121 (2) :273-279 (2003) .
Other Product Names
Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1
Tested Applications
WB, IHC-P, Flow
Protein ID
116857
Physical Properties
Liquid
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