MMP3 Antibody

Product Specifications

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

NCBI Gene ID

4314

Swiss Prot

P08254

Accession Number

P08254

Host

Rabbit

Reactivity

Human

Immunogen

This MMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the Central region of human MMP3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Symbol

MMP3

NCBI Official Name

Stromelysin-1

NCBI Organism

Homo sapiens

Background Reference 01

Sage, E.H., et al., J. Biol. Chem. 278 (39) :37849-37857 (2003) .

Background Reference 02

Matsuyama, A., et al., Circulation 108 (12) :1469-1473 (2003) .

Background Reference 03

Mercapide, J., et al., Int. J. Cancer 106 (5) :676-682 (2003) .

Background Reference 04

Bodemer, C., et al., J. Invest. Dermatol. 121 (2) :273-279 (2003) .

Other Product Names

Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1

Tested Applications

WB, IHC-P, Flow

Protein ID

116857

Physical Properties

Liquid

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