MMP24 Antibody
Product Specifications
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24) .
NCBI Gene ID
10893
Swiss Prot
Q9Y5R2
Accession Number
Q9Y5R2
Host
Rabbit
Reactivity
Human
Immunogen
This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the Central region of human MMP24.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
73 kDa
Fragment
Rabbit Ig
Symbol
MMP24
NCBI Official Name
Matrix metalloproteinase-24
NCBI Organism
Homo sapiens
Background Reference 01
Jung, M., et al., Prostate 55 (2) :89-98 (2003) .
Background Reference 02
Kajita, M., et al., FEBS Lett. 457 (3) :353-356 (1999) .
Background Reference 03
Llano, E., et al., Cancer Res. 59 (11) :2570-2576 (1999) .
Background Reference 04
Nagase, H., et al., J. Biol. Chem. 274 (31) :21491-21494 (1999) .
Other Product Names
Matrix metalloproteinase-24, MMP-24, 3424-, Membrane-type matrix metalloproteinase 5, MT-MMP 5, MTMMP5, Membrane-type-5 matrix metalloproteinase, MT5-MMP, MT5MMP, Processed matrix metalloproteinase-24, MMP24, MT5MMP
Tested Applications
WB, IHC-P
Protein ID
12585280
Physical Properties
Liquid
Curated Selection
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