MMP15 Antibody

Product Specifications

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP15 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.

NCBI Gene ID

4324

Swiss Prot

P51511

Accession Number

P51511

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MMP15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human MMP15.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

76 kDa

Fragment

Rabbit Ig

Symbol

MMP15

NCBI Official Name

Matrix metalloproteinase-15

NCBI Organism

Homo sapiens

Background Reference 01

Jung, M., et al., Prostate 55 (2) :89-98 (2003) .

Background Reference 02

Nagase, H., et al., J. Biol. Chem. 274 (31) :21491-21494 (1999) .

Background Reference 03

D'Ortho, M.P., et al., Eur. J. Biochem. 250 (3) :751-757 (1997) .

Background Reference 04

Sato, H., et al., Genomics 39 (3) :412-413 (1997) .

Other Product Names

Matrix metalloproteinase-15, MMP-15, 3424-, Membrane-type matrix metalloproteinase 2, MT-MMP 2, MTMMP2, Membrane-type-2 matrix metalloproteinase, MT2-MMP, MT2MMP, SMCP-2, MMP15