MMP14 Antibody

Product Specifications

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.

NCBI Gene ID

4323

Swiss Prot

P50281

Accession Number

P50281

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat, Pig, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

66 kDa

Fragment

Rabbit Ig

Symbol

MMP14

NCBI Official Name

Matrix metalloproteinase-14

NCBI Organism

Homo sapiens

Background Reference 01

Will, H., et al., Eur. J. Biochem. 231 (3) :602-608 (1995) .

Background Reference 02

Takino, T., et al., Gene 155 (2) :293-298 (1995) .

Background Reference 03

Okada, A., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (7) :2730-2734 (1995) .

Background Reference 04

Sato, H., et al., Nature 370 (6484) :61-65 (1994) .

Other Product Names

Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14