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MLLT1 Antibody

Product Specifications

Background

Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t (11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.

NCBI Gene ID

4298

Swiss Prot

Q03111

Accession Number

Q03111

Host

Rabbit

Reactivity

Human

Immunogen

This MLLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-552 amino acids from the C-terminal region of human MLLT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-162

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

MLLT1

NCBI Official Name

Protein ENL

NCBI Organism

Homo sapiens

Background Reference 01

Nie, Z., et al., Mol. Cell. Biol. 23 (8) :2942-2952 (2003) .

Background Reference 02

Lavau, C., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (20) :10984-10989 (2000) .

Background Reference 03

Thirman, M.J., et al., Proc. Natl. Acad. Sci. U.S.A. 91 (25) :12110-12114 (1994) .

Background Reference 04

Rubnitz, J.E., et al., Blood 84 (6) :1747-1752 (1994) .

Other Product Names

Protein ENL, YEATS domain-containing protein 1, MLLT1, ENL, LTG19, YEATS1

Tested Applications

WB

Protein ID

116241350

Physical Properties

Liquid

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