LRP6 Antibody

Product Specifications

Background

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

NCBI Gene ID

4040

Swiss Prot

O75581

Accession Number

O75581

Host

Rabbit

Reactivity

Human

Immunogen

This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

180 kDa

Fragment

Rabbit Ig

Symbol

LRP6

NCBI Official Name

Low-density lipoprotein receptor-related protein 6

NCBI Organism

Homo sapiens

Background Reference 01

Liu, G., et al., Mol. Cell. Biol. 23 (16) :5825-5835 (2003) . Tamai, K., et al., Nature 407 (6803) :530-535 (2000) . Brown, S.D., et al., Biochem. Biophys. Res. Commun. 248 (3) :879-888 (1998) .