Leptin Receptor Antibody

Product Specifications

Background

Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR) . LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.

NCBI Gene ID

3953

Swiss Prot

P48357

Accession Number

P48357

Host

Rabbit

Reactivity

Human

Immunogen

This Leptin Receptor (LEPR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the N-terminal region of human Leptin Receptor (LEPR) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

132 kDa

Fragment

Rabbit Ig

Symbol

LEPR

NCBI Official Name

Leptin receptor

NCBI Organism

Homo sapiens

Background Reference 01

Schroth, M., et al., J. Clin. Endocrinol. Metab. 88 (11) :5497-5501 (2003) .

Background Reference 02

Couturier, C., et al., J. Biol. Chem. 278 (29) :26604-26611 (2003) .

Background Reference 03

Gavrila, A., et al., J. Clin. Endocrinol. Metab. 88 (6) :2838-2843 (2003) .

Background Reference 04

Yannakoulia, M., et al., J. Clin. Endocrinol. Metab. 88 (4) :1730-1736 (2003) .

Other Product Names

Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR

Tested Applications

WB, IHC-P, Flow

Protein ID

116242617

Physical Properties

Liquid

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