HAND2 Antibody

HAND2 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

This HAND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-207 amino acids from the C-terminal region of human HAND2.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

McFadden, D.G., et al., Development 127 (24) :5331-5341 (2000) . Firulli, A.B., et al., Nat. Genet. 18 (3) :266-270 (1998) . Russell, M.W., et al., Biochim. Biophys. Acta 1443 (3) :393-399 (1998) . Srivastava, D., Trends Cardiovasc Med (1-2), 11-18 (1999) . Srivastava, D., et al., Cold Spring Harb. Symp. Quant. Biol. 67, 121-125 (2002) .

Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND, HAND2, BHLHA26, DHAND