ARHGEF3 Antibody

Product Specifications

Background

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

50650

Swiss Prot

Q9NR81

Accession Number

Q9NR81

Host

Rabbit

Reactivity

Human

Immunogen

This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

ARHGEF3

NCBI Official Name

Rho guanine nucleotide exchange factor 3

NCBI Organism

Homo sapiens

Background Reference 01

Arthur, W.T., et al. J. Biol. Chem. 277 (45) :42964-42972 (2002)

Background Reference 02

Harrington, A.W., et al. J. Neurosci. 22 (1) :156-166 (2002)

Background Reference 03

Simpson, J.C., et al. EMBO Rep. 1 (3) :287-292 (2000)

Background Reference 04

Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273 (1) :364-369 (2000)

Other Product Names

Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3

Tested Applications

WB, IHC-P

Protein ID

52782760

Physical Properties

Liquid

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