PON2 Antibody

Product Specifications

Background

PON2 is a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes.

NCBI Gene ID

5445

Swiss Prot

Q15165

Accession Number

Q15165

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PON2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-101 amino acids from the Central region of human PON2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Symbol

PON2

NCBI Official Name

Serum paraoxonase/arylesterase 2

NCBI Organism

Homo sapiens

Background Reference 01

Sanghera, D.K., et al. Am. J. Hum. Genet. 62 (1) :36-44 (1998)

Background Reference 02

Hegele, R.A., et al. J. Clin. Endocrinol. Metab. 82 (10) :3373-3377 (1997)

Background Reference 03

Primo-Parmo, S.L., et al. Genomics 33 (3) :498-507 (1996)

Other Product Names

Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2

Tested Applications

WB, IHC-P, IF

Protein ID

325511384

Physical Properties

Liquid

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