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LCLT1 Antibody

Product Specifications

Background

Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.

NCBI Gene ID

253558

Swiss Prot

Q6UWP7

Accession Number

Q6UWP7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This LCLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the C-terminal region of human LCLT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

49 kDa

Fragment

Rabbit Ig

Symbol

LCLAT1

NCBI Official Name

Lysocardiolipin acyltransferase 1

NCBI Organism

Homo sapiens

Background Reference 01

Zhao, Y., et al. J. Lipid Res. 50 (5) :945-956 (2009)

Background Reference 02

Wang, C., et al. Blood 110 (10) :3601-3609 (2007)

Background Reference 03

Agarwal, A.K., et al. Arch. Biochem. Biophys. 449 (1-2), 64-76 (2006)

Other Product Names

Lysocardiolipin acyltransferase 1, 231-, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-AGP acyltransferase 8, 1-AGPAT 8, Acyl-CoA:lysocardiolipin acyltransferase 1, LCLAT1, AGPAT8, ALCAT1, LYCAT

Tested Applications

WB, IHC-P

Protein ID

74749398

Physical Properties

Liquid

Frequently Asked Questions

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