CALCR Antibody

Product Specifications

Background

CALCR is a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis.

NCBI Gene ID

799

Swiss Prot

P30988

Accession Number

P30988

Host

Rabbit

Reactivity

Human

Immunogen

This CALCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human CALCR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Symbol

CALCR

NCBI Official Name

Calcitonin receptor

NCBI Organism

Homo sapiens

Background Reference 01

Nussenzveig, D.R., et al. Endocrinology 136 (5) :2047-2051 (1995) Nakamura, M., et al. Biochem. Biophys. Res. Commun. 209 (2) :744-751 (1995) Egerton, M., et al. J. Mol. Endocrinol. 14 (2) :179-189 (1995) Gorn, A.H., et al. J. Clin. Invest. 90 (5) :1726-1735 (1992)