IKZF3 Antibody

Product Specifications

Background

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

NCBI Gene ID

22806

Swiss Prot

Q9UKT9

Accession Number

Q9UKT9

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IKZF3

NCBI Official Name

Zinc finger protein Aiolos

NCBI Organism

Homo sapiens

Background Reference 01

Billot, K., et al. Leuk. Res. 34 (3) :289-293 (2010)

Background Reference 02

Hirschfield, G.M., et al. N. Engl. J. Med. 360 (24) :2544-2555 (2009)

Background Reference 03

Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)

Background Reference 04

Vieira, A.R., et al. Genet. Med. 10 (9) :668-674 (2008)

Other Product Names

Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3

Tested Applications

Protein ID

212276437

Physical Properties

Liquid

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