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BDHA1 Antibody

Product Specifications

Background

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) . The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex.

NCBI Gene ID

5160

Swiss Prot

P08559

Accession Number

P08559

Host

Rabbit

Reactivity

Human

Immunogen

This BDHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-255 amino acids from the Central region of human BDHA1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-972

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Symbol

PDHA1

NCBI Official Name

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Glushakova, L.G., et al. Mol. Genet. Metab. 98 (3) :289-299 (2009)

Background Reference 02

Joao Silva, M., et al. Eur. J. Pediatr. 168 (1) :17-22 (2009)

Background Reference 03

Boichard, A., et al. Mol. Genet. Metab. 93 (3) :323-330 (2008)

Other Product Names

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, PDHA1, PHE1A

Tested Applications

WB, Flow

Protein ID

129063

Physical Properties

Liquid

Curated Selection

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