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XRCC1 Antibody

Product Specifications

Background

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

NCBI Gene ID

7515

Swiss Prot

P18887

Accession Number

P18887

Host

Rabbit

Reactivity

Human

Immunogen

This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=61-969

Calculated Molecular Weight

69 kDa

Fragment

Rabbit Ig

Symbol

XRCC1

NCBI Official Name

DNA repair protein XRCC1

NCBI Organism

Homo sapiens

Background Reference 01

Lamerdin, J.E., et al. Genomics 25 (2) :547-554 (1995)

Background Reference 02

Gyapay, G., et al. Nat. Genet. (2 SPEC NO), 246-339 (1994) :

Background Reference 03

Thompson, L.H., et al. Mol. Cell. Biol. 10 (12) :6160-6171 (1990)

Background Reference 04

Thompson, L.H., et al. Genomics 5 (4) :670-679 (1989)

Other Product Names

DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

317373290

Physical Properties

Liquid

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