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B4GALT5 Antibody

Product Specifications

Background

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq].

NCBI Gene ID

9334

Swiss Prot

O43286

Accession Number

O43286

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This B4GALT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-350 amino acids from the C-terminal region of human B4GALT5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Symbol

B4GALT5

NCBI Official Name

Beta-1,4-galactosyltransferase 5

NCBI Organism

Homo sapiens

Background Reference 01

Kitayama, K., et al. J. Biol. Chem. 282 (41) :30085-30096 (2007)

Background Reference 02

Sato, T., et al. J. Biol. Chem. 282 (38) :27702-27712 (2007)

Background Reference 03

Jiang, J., et al. J. Biol. Chem. 281 (14) :9482-9489 (2006)

Background Reference 04

Sato, T., et al. J. Biol. Chem. 279 (38) :39574-39583 (2004)

Other Product Names

Beta-1,4-galactosyltransferase 5, Beta-1,4-GalTase 5, Beta4Gal-T5, b4Gal-T5, 241-, Beta-1,4-GalT II, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5, B4GALT5

Tested Applications

WB, Flow

Physical Properties

Liquid

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