HMGA2 Antibody

Product Specifications

Background

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NCBI Gene ID

8091

Swiss Prot

P52926

Accession Number

P52926

Host

Rabbit

Reactivity

Human

Immunogen

This HMGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

12 kDa

Fragment

Rabbit Ig

Symbol

HMGA2

NCBI Official Name

High mobility group protein HMGI-C

NCBI Organism

Homo sapiens

Background Reference 01

Mu, G., et al. Hum. Pathol. 41 (4) :493-502 (2010)

Background Reference 02

Pillas, D., et al. PLoS Genet. (2), E1000856 (2010) :

Background Reference 03

Yang, T.L., et al. Ann. Hum. Genet. 74 (1) :11-16 (2010)

Background Reference 04

Wei, J.J., et al. Am. J. Surg. Pathol. 34 (1) :18-26 (2010)

Other Product Names

High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC

Tested Applications

WB, Flow

Protein ID

1708263

Physical Properties

Liquid

Curated Selection

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