GNE Antibody
Product Specifications
Background
GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
NCBI Gene ID
10020
Swiss Prot
Q9Y223
Accession Number
Q9Y223
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 580-607 amino acids from the C-terminal region of human GNE.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Hamster, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-879
Calculated Molecular Weight
79 kDa
Fragment
Rabbit Ig
Symbol
GNE
NCBI Official Name
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
NCBI Organism
Homo sapiens
Background Reference 01
Reinke, S.O., et al. Glycoconj. J. 26 (4) :415-422 (2009)
Background Reference 02
Tong, Y., et al. PLoS ONE (10), E7165 (2009)
Background Reference 03
Klootwijk, R.D., et al. FASEB J. 22 (11) :3846-3852 (2008)
Other Product Names
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE
Tested Applications
WB, Flow
Protein ID
45476991
Physical Properties
Liquid
Curated Selection
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