GMNN Antibody
Product Specifications
Background
GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC) . It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
NCBI Gene ID
51053
Swiss Prot
O75496
Accession Number
O75496
Host
Rabbit
Reactivity
Human
Immunogen
This GMNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human GMNN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Symbol
GMNN
NCBI Official Name
Geminin
NCBI Organism
Homo sapiens
Background Reference 01
De Marco, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (47) :19807-19812 (2009)
Background Reference 02
Zhu, W., et al. Cancer Res. 69 (11) :4870-4877 (2009)
Background Reference 03
Lu, F., et al. Biol. Cell 101 (5) :273-285 (2009)
Other Product Names
Geminin, GMNN
Tested Applications
WB, IHC-P
Physical Properties
Liquid
Curated Selection
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