ATP4B Antibody

Product Specifications

Background

ATP4B belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H (+) and K (+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase.

NCBI Gene ID

496

Swiss Prot

P51164

Accession Number

P51164

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ATP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human ATP4B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Symbol

ATP4B

NCBI Official Name

Potassium-transporting ATPase subunit beta

NCBI Organism

Homo sapiens

Background Reference 01

Bab-Dinitz, E., et al. Biochemistry 48 (36) :8684-8691 (2009) Knouff, C.W., et al. Pharmacogenet. Genomics 18 (12) :1051-1057 (2008) Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)