CREBL1 Antibody

Product Specifications

Background

CREBL1 is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus.

NCBI Gene ID

1388

Swiss Prot

Q99941

Accession Number

Q99941

Host

Rabbit

Reactivity

Human, Mouse, Hamster

Immunogen

This CREBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-589 amino acids from the C-terminal region of human CREBL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

77 kDa

Fragment

Rabbit Ig

Symbol

ATF6B

NCBI Official Name

Cyclic AMP-dependent transcription factor ATF-6 beta

NCBI Organism

Homo sapiens

Background Reference 01

Guan, D., et al. J. Cell. Biochem. 108 (4) :825-831 (2009)

Background Reference 02

Barcellos, L.F., et al. PLoS Genet. (10), E1000696 (2009)

Background Reference 03

Thuerauf, D.J., et al. J. Biol. Chem. 279 (20) :21078-21084 (2004)

Other Product Names

Cyclic AMP-dependent transcription factor ATF-6 beta, cAMP-dependent transcription factor ATF-6 beta, Activating transcription factor 6 beta, ATF6-beta, Protein G13, cAMP response element-binding protein-related protein, Creb-rp, cAMP-responsive element-binding protein-like 1, Processed cyclic AMP-dependent transcription factor ATF-6 beta, ATF6B, CREBL1, G13