XRCC6 Antibody
Product Specifications
Background
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V (D) J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
NCBI Gene ID
2547
Swiss Prot
P12956
Accession Number
P12956
Host
Rabbit
Reactivity
Human
Immunogen
This XRCC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-548 amino acids from the C-terminal region of human XRCC6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=61-786
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Symbol
XRCC6
NCBI Official Name
X-ray repair cross-complementing protein 6
NCBI Organism
Homo sapiens
Background Reference 01
Vishnudas, V.K., et al. Hum. Mol. Genet. 18 (23) :4467-4477 (2009)
Background Reference 02
Wang, Q., et al. Neoplasia 11 (10) :1012-1021 (2009)
Background Reference 03
Beskow, C., et al. Br. J. Cancer 101 (5) :816-821 (2009)
Other Product Names
X-ray repair cross-complementing protein 6, 364-, 4299-, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, XRCC6, G22P1
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
125729
Physical Properties
Liquid
Curated Selection
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