PAAF1 Antibody
Product Specifications
Background
PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency.
NCBI Gene ID
80227
Swiss Prot
Q9BRP4
Accession Number
Q9BRP4
Host
Rabbit
Reactivity
Human
Immunogen
This PAAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the N-terminal region of human PAAF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Symbol
PAAF1
NCBI Official Name
Proteasomal ATPase-associated factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Lassot, I., et al. Mol. Cell 25 (3) :369-383 (2007)
Background Reference 02
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)
Background Reference 03
Ponnappan, S., et al. Int. J. Biochem. Cell Biol. 39 (4) :799-809 (2007)
Other Product Names
Proteasomal ATPase-associated factor 1, Protein G-16, WD repeat-containing protein 71, PAAF1, WDR71
Tested Applications
WB, IHC-P
Protein ID
97217547
Physical Properties
Liquid
Curated Selection
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