HSPA5 Antibody

When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER) . Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.

This HSPA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the Central region of human HSPA5.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Zhao, C., et al. J. Med. Virol. 82 (1) :14-22 (2010) Zhuang, L., et al. Mod. Pathol. 23 (1) :45-53 (2010) Arnaudeau, S., et al. Proteomics 9 (23) :5316-5327 (2009)

78 kDa glucose-regulated protein, GRP-78, Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP, HSPA5, GRP78