HSPA5 Antibody
Product Specifications
Background
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER) . Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.
NCBI Gene ID
3309
Swiss Prot
P11021
Accession Number
P11021
Host
Rabbit
Reactivity
Human
Immunogen
This HSPA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-568 amino acids from the C-terminal region of human HSPA5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
72 kDa
Fragment
Rabbit Ig
Symbol
HSPA5
NCBI Official Name
78 kDa glucose-regulated protein
NCBI Organism
Homo sapiens
Background Reference 01
Zhao, C., et al. J. Med. Virol. 82 (1) :14-22 (2010)
Background Reference 02
Zhuang, L., et al. Mod. Pathol. 23 (1) :45-53 (2010)
Background Reference 03
Arnaudeau, S., et al. Proteomics 9 (23) :5316-5327 (2009)
Other Product Names
78 kDa glucose-regulated protein, GRP-78, Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP, HSPA5, GRP78
Tested Applications
WB, IHC-P, Flow
Protein ID
14916999
Physical Properties
Liquid
Curated Selection
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