CHRNA3 Antibody
Product Specifications
Background
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
NCBI Gene ID
1136
Swiss Prot
P32297
Accession Number
P32297
Host
Rabbit
Reactivity
Human
Immunogen
This CHRNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-52 amino acids from the N-terminal region of human CHRNA3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
CHRNA3
NCBI Official Name
Neuronal acetylcholine receptor subunit alpha-3
NCBI Organism
Homo sapiens
Background Reference 01
Cho, M.H., et al. Nat. Genet. 42 (3) :200-202 (2010)
Background Reference 02
Girard, N., et al. Clin. Cancer Res. 16 (2) :755-763 (2010)
Background Reference 03
Grando, S.A., et al. J. Invest. Dermatol. 105 (6) :774-781 (1995)
Other Product Names
Neuronal acetylcholine receptor subunit alpha-3, CHRNA3, NACHRA3
Tested Applications
WB, IHC-P
Protein ID
254763435
Physical Properties
Liquid
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