PNPLA8 Antibody

Product Specifications

Background

PNPLA8 catalyzes cleavage of fatty acids from phospholipids, thereby regulating membrane physical properties and the release of lipid second messengers and growth factors. Phospholipase A2 activity also modulates cellular growth programs, inflammation, and ion channel function.

NCBI Gene ID

50640

Swiss Prot

Q9NP80

Accession Number

Q9NP80

Host

Rabbit

Reactivity

Human

Immunogen

This PNPLA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the N-terminal region of human PNPLA8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

88 kDa

Fragment

Rabbit Ig

Symbol

PNPLA8

NCBI Official Name

Calcium-independent phospholipase A2-gamma

NCBI Organism

Homo sapiens

Background Reference 01

Harper, M.T., et al. J. Thromb. Haemost. 6 (10) :1819-1821 (2008)

Background Reference 02

Wilson, P.A., et al. J. Lipid Res. 47 (9) :1940-1949 (2006)

Background Reference 03

Murakami, M., et al. J. Biol. Chem. 280 (14) :14028-14041 (2005)

Other Product Names

Calcium-independent phospholipase A2-gamma, Intracellular membrane-associated calcium-independent phospholipase A2 gamma, iPLA2-gamma, PNPLA-gamma, Patatin-like phospholipase domain-containing protein 8, iPLA2-2, PNPLA8, IPLA22, IPLA2G