PHGDH Antibody

Product Specifications

Background

3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.

NCBI Gene ID

26227

Swiss Prot

O43175

Accession Number

O43175

Host

Rabbit

Reactivity

Human

Immunogen

This PHGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human PHGDH.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

PHGDH

NCBI Official Name

D-3-phosphoglycerate dehydrogenase

NCBI Organism

Homo sapiens

Background Reference 01

Du, H., et al. Reproduction 139 (1) :237-245 (2010)

Background Reference 02

Burton, R.L., et al. Biochemistry 48 (22) :4808-4815 (2009)

Background Reference 03

Kim, J.W., et al. Psychiatr. Genet. 19 (3), 161 (2009) :

Background Reference 04

Tabatabaie, L., et al. Hum. Mutat. 30 (5) :749-756 (2009)

Other Product Names

D-3-phosphoglycerate dehydrogenase, 3-PGDH, PHGDH, PGDH3

Tested Applications

WB, IHC-P, Flow

Physical Properties

Liquid

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